Amylin mimetics have what impact on the absorption of oral medications?

• A. Delays gastric emptying but does not affect absorption
• B. Delays PO drug absorption
• C. Speeds up absorption of oral medications
• D. Has no effect on gastric emptying or absorption

Answer: (B)

Amylin mimetics slow gastric emptying, so the movement of chyme from the stomach into the small intestine is delayed. Since most oral medications are absorbed mainly in the small intestine, this slower transit means the drug sits in the stomach longer before absorption can begin, pushing back the onset of action and delaying peak concentrations. The total amount absorbed for many drugs may not change, but the rate is slower. Therefore, the effect is best described as delaying oral drug absorption.