MOA of amylin mimetics like pramlintide?

• A. Delay gastric emptying and suppress glucagon secretion
• B. Stimulate glucagon release
• C. Increase hepatic glucose production
• D. Block insulin action

Answer: (A)

Amylin mimetics behave like amylin, a hormone co-secreted with insulin from pancreatic beta cells. Their primary effects are to slow gastric emptying, which blunts the speed at which glucose enters the bloodstream after a meal, and to suppress glucagon secretion during the postprandial period, reducing hepatic glucose production when it would otherwise spike. Together, these actions lessen post-meal glucose rises and improve overall glycemic control. They do not stimulate glucagon release, do not increase hepatic glucose production, and do not block insulin action; in fact, pramlintide is used alongside insulin and can require dose adjustments to avoid hypoglycemia.