Pramlintide is an amylin mimetic used with insulin in which diabetes types?

• A. Type 1 and Type 2 diabetes
• B. Gestational diabetes
• C. Type 2 diabetes only
• D. Type 1 diabetes only

Answer: (A)

Pramlintide is an amylin mimetic used as an adjunct to mealtime insulin to improve postprandial glucose control. Amylin is a hormone normally co-secreted with insulin, and pramlintide mimics its effects: it slows gastric emptying, suppresses glucagon secretion after meals, and increases satiety. These actions help blunt the rise in blood glucose after eating, which is beneficial in both type 1 and type 2 diabetes when patients rely on mealtime insulin but still struggle with postprandial spikes. It is not indicated for gestational diabetes. Because it changes how quickly glucose enters the bloodstream, dosing must be coordinated with insulin to minimize hypoglycemia, and patients need to adjust insulin doses accordingly.