Repaglinide is primarily eliminated by which organ?

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Multiple Choice

Repaglinide is primarily eliminated by which organ?

Explanation:
Repaglinide is eliminated mainly by the liver through metabolism. It is rapidly metabolized in the liver to inactive forms, so most of its clearance comes from hepatic processing rather than renal excretion. Only a small amount is excreted unchanged by the kidneys, making the liver the primary elimination organ. This also means hepatic impairment can increase drug exposure and require caution. The lungs or spleen do not contribute meaningfully to its elimination.

Repaglinide is eliminated mainly by the liver through metabolism. It is rapidly metabolized in the liver to inactive forms, so most of its clearance comes from hepatic processing rather than renal excretion. Only a small amount is excreted unchanged by the kidneys, making the liver the primary elimination organ. This also means hepatic impairment can increase drug exposure and require caution. The lungs or spleen do not contribute meaningfully to its elimination.

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