SGLT-2 inhibitors work by increasing urinary glucose excretion.

• A. True
• B. False
• C. Not a mechanism
• D. They are insulin secretagogues

Answer: (A)

SGLT-2 inhibitors lower blood glucose by blocking glucose reabsorption in the kidneys. They inhibit SGLT-2 transporters in the proximal tubule, so filtered glucose isn’t reabsorbed and is excreted in the urine (glucosuria). This mechanism reduces plasma glucose independently of insulin, which is why these drugs can help even if beta-cell function is limited. That’s why the statement is true. They are not insulin secretagogues, since they do not stimulate insulin release.