Which of the following is NOT a DPP-4 inhibitor?

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Multiple Choice

Which of the following is NOT a DPP-4 inhibitor?

Explanation:
Understanding how DPP-4 inhibitors work and how metformin differs in its action helps identify the correct choice. DPP-4 inhibitors block the enzyme that breaks down incretin hormones like GLP-1 and GIP, so these hormones stay active longer. That boosts glucose-dependent insulin secretion and suppresses glucagon, helping lower blood glucose without causing much hypoglycemia. Drugs in this class include sitagliptin, saxagliptin, and linagliptin, which is why they are DPP-4 inhibitors. Metformin does not affect DPP-4; it lowers hepatic glucose production and improves insulin sensitivity, mainly through activating AMPK. So the medication that is NOT a DPP-4 inhibitor is metformin.

Understanding how DPP-4 inhibitors work and how metformin differs in its action helps identify the correct choice. DPP-4 inhibitors block the enzyme that breaks down incretin hormones like GLP-1 and GIP, so these hormones stay active longer. That boosts glucose-dependent insulin secretion and suppresses glucagon, helping lower blood glucose without causing much hypoglycemia. Drugs in this class include sitagliptin, saxagliptin, and linagliptin, which is why they are DPP-4 inhibitors. Metformin does not affect DPP-4; it lowers hepatic glucose production and improves insulin sensitivity, mainly through activating AMPK. So the medication that is NOT a DPP-4 inhibitor is metformin.

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