Which of the following is a GLP-1 receptor agonist used for type 2 diabetes and weight loss?

• A. Metformin
• B. Semaglutide
• C. Dapagliflozin
• D. Lisinopril

Answer: (B)

GLP-1 receptor agonists mimic the incretin hormone GLP-1, boosting insulin release in a glucose-dependent way, slowing gastric emptying, and decreasing appetite to promote weight loss. Semaglutide fits this profile as a long-acting GLP-1 receptor agonist that is used in type 2 diabetes and has proven effects on reducing weight. The other drugs listed work through different mechanisms: metformin lowers hepatic glucose production and improves insulin sensitivity but does not activate GLP-1 receptors; dapagliflozin is an SGLT2 inhibitor that increases glucose excretion in the urine; lisinopril is an ACE inhibitor used for blood pressure. Therefore, semaglutide is the option that aligns with both type 2 diabetes treatment and weight loss.